hydrochlorothiazide
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Hydrochlorothiazide
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| Systematic (IUPAC) name |
6-chloro-3,4-dihydro-2H-
1,2,4-benzothiadiazine-
7-sulfonamide 1,1-dioxide |
| Identifiers |
| CAS number |
58-93-5 |
| ATC code |
C03AA03 |
| PubChem |
3639 |
| Chemical data |
| Formula |
C7H8ClN3O4S2 |
| Mol. weight |
297.742 |
| Pharmacokinetic data |
| Bioavailability |
Variably absorbed from GI tract |
| Metabolism |
? |
| Half life |
5.6-14.8 hours |
| Excretion |
Primarily excreted unchanged in urine |
| Therapeutic considerations |
| Pregnancy cat. |
B (D if used to treat pregnancy-induced hypertension)
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| Legal status |
℞ Prescription only
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| Routes |
Oral (capsules, tablets, oral solution) |
Hydrochlorothiazide (Apo-Hydro®, Aquazide H®, Dichlotride®, Hydrodiuril®, Microzide®, Oretic®), sometimes abbreviated HCT, HCTZ, or HZT is a popular diuretic drug that acts by inhibiting the kidney's ability to retain water. This reduces the volume of the blood, decreasing peripheral vascular resistance.
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Contents
- 1 Activity
- 2 Indications
- 3 Side effects
- 4 External links
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Activity
Hydrochlorothiazide belongs to the thiazide class of diuretics, acting on the kidney to reduce sodium (Na) reabsorption in the distal convoluted tubule. This reduces the osmotic pressure in the kidney, causing less water to be reabsorbed by the collecting ducts.
Indications
HCT is often used to treat hypertension, congestive heart failure, symptomatic edema and prevention of kidney stones. It is effective in diabetes insipidus and is also sometimes used in hypercalciuria.
Hypokalemia, an occasional side-effect, can be usually prevented by potassium supplements or combining hydrochlorothiazide with a potassium-sparing diuretic.
Side effects
- Hypokalemia
- Hypomagnesemia
- Hyperuricemia and gout
- High blood sugar
- High cholesterol
- Headache
- Impotence
External links
- Link page to external chemical sources.
| Antihypertensives (C02) and diuretics (C03) edit |
| Antiadrenergic agents: |
Clonidine, Doxazosin, Guanethidine, Guanfacine, Mecamylamine, Methyldopa, Moxonidine, Prazosin, Rescinnamine, Reserpine
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| Vasodilators: |
Diazoxide, Hydralazine, Minoxidil, Nitroprusside, Phentolamine
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| Other antihypertensives: |
Bosentan, Ketanserin
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| Low ceiling diuretics: |
Bendroflumethiazide, Chlorothiazide, Chlortalidone, Hydrochlorothiazide, Indapamide, Quinethazone, Mersalyl, Metolazone, Theobromine
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| High ceiling diuretics: |
Bumetanide, Furosemide, Torasemide
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| Potassium-sparing diuretics: |
Amiloride, Eplerenone, Spironolactone, Triamterene
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hydrochlorothiazide news and hydrochlorothiazide articles
Here's our top rated
hydrochlorothiazide links for the day:
New Study Confirms WelChol Improves Glycemic Control In Patients With Uncontrolled Type 2 Diabetes Mellitus On Insulin
Medical News Today - Nov 16 12:08 AM Data presented today at the American Heart Association's (AHA) Scientific Sessions 2006 in Chicago demonstrated that WelChol(R) (colesevelam HCl), when added to insulin in uncontrolled patients with type 2 diabetes mellitus, improves glycemic control. This is the first study ever to evaluate WelChol in combination with insulin, and it demonstrated A1C reductions of 0. [click link for full article]
Wal-Mart Brings $4 Generics Program to Idaho
[Press Release] PR Newswire via Yahoo! Finance - Nov 16 3:00 AM Wal-Mart Stores, Inc., announced that its 20 pharmacies in Idaho will begin participating in Wal-Mart's $4 generic prescription program starting today. In addition, the company announced that it is adding 17 more prescriptions to the program.
Wal-Mart Brings $4 Generics Program to Massachusetts
[Press Release] PR Newswire via Yahoo! Finance - Nov 16 3:00 AM Wal-Mart Stores, Inc., announced that its 44 pharmacies in Massachusetts will begin participating in Wal-Mart's $4 generic prescription program starting today. In addition, the company announced that it is adding 17 more prescriptions to the program.
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